Combine lifespan, healthspan, and biological age measurements in a single experiment. Discover a smarter way to accelerate nutraceutical innovation. At Nagi Bioscience, we fast-track the development of healthy aging products through our multi-endpoint strategy, combining lifespan, healthspan, and biological age measurements in a single automated experiment. Our AI-driven Nagi™ C-Age and B-Age assays deliver translational…
Insights from C. elegans screening with SydLab™ One Discover how ElixIRA Pharma leveraged high-throughput in vivo screening to evaluate the synergistic effects of two compounds (E1 and E2) on lifespan, motility, and biological age, using automated and AI-driven analysis. What you’ll learn: How integrating phenotypic readouts early can de-risk candidate selection by identifying efficacy and…
Alzheimer’s disease (AD), the most common form of dementia, is an age-related disease strongly associated with mitochondrial dysfunction and metabolic imbalance, both of which accelerate cellular and neuronal decline. Mitochondrial dysfunction, such as mitochondrial hypermetabolism, has been identified as a critical event in the onset and progression of AD. In parallel, caloric restriction (CR) stands…
𝖶𝗁𝖺𝗍 𝗂𝖿 𝗐𝖾 𝖼𝗈𝗎𝗅𝖽 𝗆𝖾𝖺𝗌𝗎𝗋𝖾 𝖻𝗂𝗈𝗅𝗈𝗀𝗂𝖼𝖺𝗅 𝖺𝗀𝖾, 𝗁𝖾𝖺𝗅𝗍𝗁𝗌𝗉𝖺𝗇, 𝖺𝗇𝖽 𝗅𝗂𝖿𝖾𝗌𝗉𝖺𝗇 𝖺𝗅𝗅 𝖺𝗍 𝗈𝗇𝖼𝖾? Learn how experts are transforming the way we discover interventions in aging and neurodegeneration in our webinar. Join us for a thought-provoking 40-minutes session where leading experts will share cutting-edge insights at the intersection of fundamental science and translational innovation: Prof. Konstantinos…
Explore how to combine lifespan, healthspan, and biological age measurements in a single experiment. What to expect from this snapshot guide: Current challenges in longevity and aging research: Bringing interventions from the lab to the market. A multi-endpoint, one-shot approach: lifespan, healthspan, and biological age measurements at once. Applying C-Age and B-Age assays: Doxycycline interventions.…
Nagi™ B-Age is a fully automated, AI-powered assay that measures biological age in C. elegans using high-content images acquired through the SydLab™ One platform. This multiparametric approach evaluates over 20 phenotypic biomarkers to assess five vital traits. These traits represent how the organism allocates energy across its lifespan. The biological age values are computed for…
High-throughput analysis is a challenge in C. elegans research. One example is the conduction of lifespan assays that rely on heavy manual work for a long period of time. In response, we devel- oped a robotic microfluidic-based platform, the SydLab™ One, capable of handling culture, treatment, and imaging of up to 64 worm populations in…
C. elegans is a powerful model organism for biomedical studies. However, the traditional proto- cols, which continue to be broadly used, rely on manual handling, making them labor-intensive and time-consuming. Automation of these processes would greatly benefit long-term studies of C. elegans. Significant progress has been achieved over the past decade in the techniques to…
As aging research remains at the forefront of biomedical science and an increasingly growing social issue, understanding the biological mechanisms behind cellular and organismal decline is crucial to extending healthspan — the period of life spent in good health — and overall lifespan. Despite the need to accelerate the discovery of preventive aging interventions, traditional…