High-Throughput Aging and Longevity CRO Services
Advance your longevity pipeline with ethical, in vivo, high-throughput assays combining functional and aging biomarkers across lifespan.
Facing persistent bottlenecks with traditional aging models and methods?
Long experimental timelines.
Months to years before measurable outcomes.
High operational and ethical burdens associated with vertebrate models.
Low throughput makes it difficult to screen multiple longevity or anti-aging compounds.
Limited mechanistic insights at early stages of compound evaluation.
These constraints slow down decision-making and make it difficult to build a strong preclinical package for aging, healthspan, and longevity interventions.
At the same time, regulators, investors, consumers, and internal teams need robust evidence, validated readouts, and mechanisms of action quickly.
We are here to change that
Right Model
- Fast
- High translational value
- Ethical: A NAMs model
Used from more than 30 years in aging research, the C. elegans model has a big translational impact and allows to quickly test hypothesis and take confident decisions, earlier.
Right Test
- Automated
- Standardized
- Reproducible
A fully automated workflow that increasing precision, significance and reproducibility.
In vivo lifespan, healthspan, biological age measurements, and mechanistic insights in one shot.
Right insights
- Beyond lifespan
- Biological age insights
- Predictive and actionable data
Actionable results to take faster decisions in few days, without ethical hurdles.
C. elegans-proven, Human-potential: From model to market
The Nagi Advantage
High-Throughput in vivo aging studies at the in vitro scale
CUTTING-EDGE PLATFORM FOR HIGH-THROUGHPUT STUDIES
WORLD-CLASS EXPERTS DEDICATED TO YOU
POWERFUL IN VIVO MODEL FOR in longevity research
We provide high-throughput, fully automated aging and longevity studies using C.elegans, a well-established model organism in longevity research due to its genetic relevance, short lifespan, transparent body, and predictive value for conserved aging pathways.
Using our proprietary platform SydLab™ One, we perform continuous, high-resolution phenotyping throughout the organism’s lifespan under strictly controlled environmental conditions.
Our AI-driven complementary assays
Nagi™ C-Age
High-throughput in vivo measurement of lifespan and motility.
Multidimensional insights in a single assay.
Nagi™ B-Age
AI-powered in vivo biological age and healthspan measurement to fast-track your innovation in just 10 days.
Dissect the mechanism of action among 5 vital traits.
Combine B-Age + C-Age for Maximum Insight
Run together within the same experiment, this assay combination provides a multi-layered, high-content view of aging, correlating behavioural, functional, and vital traits aging trajectories.
Biomarkers
- Mean and Maximum Lifespan.
- Healthspan: Motility, Growth Parameters, and Reproduction.
- Biological Age
- 5 Vital Traits (health map)
Obtain a multidimensional, integrative view of aging
Deeper mechanistic insights in just one experiment.
Earlier identification of promising longevity compounds.
Improved translational power compared to single-modal assays.
Case Study: Lifespan and Healthspan analysis
We evaluated the effects of Paraquat and Nicotinamide (NAM) treatments against control conditions using two approaches: Nagi Bioscience’s fully automated SydLab™ One platform and traditional manual annotations.
The SydLab™ One platform accurately quantifies the expected lifespan changes in C. elegans subjected to varying treatments. It demonstrates the anticipated lifespan shortening with increasing concentrations of Paraquat and the lifespan extension with higher doses of Nicotinamide. The results obtained with the SydLab™ One platform are consistent with those obtained through manual plate-based assays, while increasing reproducibility and reducing time-to-results.
To delve deeper, we investigated the effects of varying levels of caloric restriction on
C. elegans.
The SydLab™ One platform quantified the expected lifespan extension resulting from progressive food dilution interventions (A), aligning with existing literature (66% of ad libitum: +10%; 33% of ad libitum: +39%). Phenotypic analysis reveals that both food dilution interventions significantly enhance motility (B), a hallmark of increased healthspan, while negatively impacting reproduction and worm size (C). Furthermore, food dilution significantly preserves intestinal integrity during aging, as evidenced by a higher intestine diameter-to-body diameter ratio (D).
“We are very pleased with Nagi Bioscience. Their innovative technology has been instrumental in allowing us to gather critical scientific data quickly, providing invaluable insights that significantly advance our research in longevity.“
“Their services revealed new insights and opened up exciting possibilities for exploring the potential of our strains in health applications related to healthy aging, helping us advance our research further.“
“Their high-throughput approach provided clear, quantifiable insights into the lifespan and functional effects of our lead combinations— critical data that helped de-risk and prioritize our therapeutic strategy.“
Add-On Options for Enhanced Insights
Evaluate Mitochondrial Function and Energy Expenditure
Mitochondrial respiration is a key indicator of cellular energy status and physiological decline in aging, metabolic disorders, and neurodegeneration.
By integrating Seahorse-based OCR analysis into SydLab™ One readouts, we provide a complementary, functional assessment of mitochondrial performance.
High-Resolution Confocal Imaging in C. elegans
Confocal microscopy offers unparalleled resolution for detailed visualization of mitochondria, muscle fibers, and autophagosomes, and other subcellular structures in
C. elegans.
Obtain mechanistic insights into physiological and pathological processes.
Gene Expression Profiling in C. elegans
To complete SydLab™ One’s robust phenotypic assessment, we introduce a gene expression profiling add-on, delivering transcriptomic data via both qPCR or RNA-seq.
Support biomarker discovery, mechanism-of-action (MOA) validation, and hypothesis generation.
Our commitment to you and your team
At Nagi Bioscience, we are more than just a CRO. We are a strategic partner dedicated to your success. Our team of experts brings 50+ years of combined experience, passion for innovation, and the commitment to delivering actionable insights.
TRUSTED BY OVER
20 TEAMS IN 12+ COUNTRIES
We start by understanding your goals
Send us your compounds or ingredients of interest
Project kick-off:
Execute and Analyze with Expertise
Report delivery:
Your actionable insights and thorough scientific follow-up