Aging and longevity studies
By combining an in vivo model and our cutting-edge technology, Nagi Bioscience delivers precise, actionable results to help researchers uncover strategies that extend healthspan and lifespan.
Our solution enables ethical and efficient testing of treatments, providing valuable insights into aging pathways. With a streamlined workflow, we accelerate the discovery, development, and de-risking of candidate therapeutics, ultimately shortening the time to market and promoting longer, healthier lives.
C. elegans: A gateway to aging research
Caenorhabditis elegans is a key tool in aging research, offering a short lifespan and genetic similarities to humans for rapid study of healthspan and lifespan interventions. This model is essential in unraveling the biological mechanisms of aging, identifying compounds and pathways that can delay age-related decline.
As a whole organism, C. elegans provides a more integrated system than cell cultures, while avoiding the ethical and logistical challenges of vertebrate models.
Today, discoveries gained from C. elegans research are guiding the development of novel therapeutic strategies to preserve human health and address age-related diseases, driving progress toward longer, healthier lives.
The Nagi Advantage
CUTTING-EDGE PLATFORM FOR HIGH-THOURGHPUT STUDIES
WORLD-CLASS EXPERTS DEDICATED TO YOU
POWERFUL IN VIVO MODEL FOR FAST AND ETHICAL TESTING
In vivo healthspan and lifespan at the in vitro scale.
Our standardized protocols and automated workflow ensure consistent, actionable results.
To support your publications.
The powerful C. elegans model delivers high translational value, making it a proven cornerstone in aging research.
The advanced high-content imaging of our SydLab™ One platform enables the visualization and analysis of diverse phenotypes, supporting wider range of applications.
From research to results: Our approach
- Synchronized populations of C. elegans (L4 larval stage) are injected into the SydLab™ One platform (day 0)
- SydLab™ One tightly controls the liquid environment to which each worm is exposed, including the compounds to be tested.
- Images or videos are acquired via time-lapse microscopy at the desired frequency.
- Our AI-based algorithm precisely measures all aging-related parameters for each individual C. elegans, and provides a detailed analysis of the entire population.
- The experiment ends when no nematodes are alive.
Readouts
- Growth
- Healthspan: Reproductive, Motility, Intestinal Atrophy.
- Lifespan: Survival.
Case Study: Lifespan and Healthspan analysis
We evaluated the effects of Paraquat and Nicotinamide (NAM) treatments against control conditions using two approaches: Nagi Bioscience’s fully automated SydLab™ One platform and traditional manual annotations.
The SydLab™ One platform accurately quantifies the expected lifespan changes in C. elegans subjected to varying treatments. It demonstrates the anticipated lifespan shortening with increasing concentrations of Paraquat and the lifespan extension with higher doses of Nicotinamide. The results obtained with the SydLab™ One platform are consistent with those obtained through manual plate-based assays, while increasing reproducibility and reducing time-to-results.
To delve deeper, we investigated the effects of varying levels of caloric restriction on
C. elegans.
The SydLab™ One platform quantified the expected lifespan extension resulting from progressive food dilution interventions (A), aligning with existing literature (66% of ad libitum: +10%; 33% of ad libitum: +39%). Phenotypic analysis reveals that both food dilution interventions significantly enhance motility (B), a hallmark of increased healthspan, while negatively impacting reproduction and worm size (C). Furthermore, food dilution significantly preserves intestinal integrity during aging, as evidenced by a higher intestine diameter-to-body diameter ratio (D).
Further references
Our commitment to you and your team
At Nagi Bioscience, we are more than just a service laboratory. We are a strategic partner dedicated to your success. Our team of experts brings 50+ years of experience, a passion for innovation, and a commitment to delivering actionable insights.
Initial Discussions:
Understanding your requirements
Send us your compounds of interest
Project kick-off:
Execute with Expertise
Report delivery:
High quality reports with actionable insights