Neurodegenerative
studies
Using an in vivo model and cutting-edge technology, Nagi Bioscience delivers precise, actionable results to help researchers uncover strategies to develop therapies and interventions against neurodegeneration.
Our solution enables ethical, efficient testing of treatments, providing valuable insights into the mechanisms driving neuronal decline. With a streamlined workflow, Nagi Bioscience accelerates the discovery, development, and de-risking of candidate therapeutics addressing neurodegenerative diseases and advancing treatments to preserve cognitive function and improve quality of life.
C. elegans: A gateway to understanding neurodegeneration
Caenorhabditis elegans is a powerful and validated model for studying neurodegenerative diseases like Alzheimer’s, Parkinson’s, Huntington’s, and ALS.
With 302 fully mapped neurons and conserved human genetic pathways, it enables detailed exploration of neural mechanisms. Its short lifespan and genetic tractability support high-throughput screening and precise modeling of disease-associated proteins.
Research using C. elegans has uncovered key insights into protein aggregation, mitochondrial dysfunction, and autophagy, advancing therapeutic discovery. The C. elegans model offers an efficient, translationally relevant platform to accelerate and de-risk neurodegenerative drug development.
The Nagi Advantage
CUTTING-EDGE PLATFORM FOR HIGH-THOURGHPUT STUDIES
WORLD-CLASS EXPERTS DEDICATED TO YOU
POWERFUL IN VIVO MODEL FOR FAST AND ETHICAL TESTING
Disease models are available for Alzheimer’s, Parkinson’s, Huntington’s, and ALS, and provides high translational value.
Fluorescence markers recapitulating the molecular progression of the disease can be easily monitored and quantified.
In vivo healthspan and lifespan at the in vitro scale.
Our standardized protocols and automated workflow ensure consistent, actionable results.
To support your publications.
From research to results: Our approach
- Synchronized populations of C. elegans (L4 larval stage) are injected into the SydLab™ One platform (day 0)
- SydLab™ One tightly controls the liquid environment to which each worm is exposed, including the treatments to be tested.
- Images or videos are acquired via time-lapse microscopy at the desired frequency.
- Our AI-based algorithm detects growth, reproductive and death parameters of individual C. elegans, and provide a detailed analysis for the nematode population.
- The experiment ends at the desired time (tipically after 7-10 days).
Readouts
- Growth
- Healthspan: Reproductive, Motility, Intestinal Atrophy.
- Fluorescence: Functional, Mechanism of Action.
Case Study: Lifespan and Healthspan analysis
Using Nagi Bioscience’s fully automated solution, we assessed the motility of a model for ALS. Additionally, we monitored and quantified SOD1-YFP protein levels associated with ALS progression.
The SydLab™ One platform captures the age-related decline in motility (a readout of healthspan) in both WT and ALS models, with the ALS model exhibiting significantly lower motility compared to WT up to day 7.
Additionally, the SydLab™ One platform enables the visualization and quantification of YFP-tagged SOD1 in the ALS model. From day 1 to day 6, it detects a marked increase of expansion in aggregate area, while the number of protein aggregates remains the same.
Further references
Our commitment to you and your team
At Nagi Bioscience, we are more than just a service laboratory. We are a strategic partner dedicated to your success. Our team of experts brings 50+ years of experience, a passion for innovation, and a commitment to delivering actionable insights.
Initial Discussions:
Understanding your requirements
Send us your compounds of interest
Project kick-off:
Execute with Expertise
Report delivery:
High quality reports with actionable insights