C. elegans is a powerful model organism for ageing studies. However, the traditional protocols, which continue to be broadly used, rely on manual handling, making them labor-intensive and time-consuming. Automation of these…
Here we describe an innovative microfluidic platform using the nematode Caenorhabditis elegans, as an ideal model organism for the study of aging due to its short lifespan and tractable genetics. Our platform allows…
Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and…
Making muscle work better Degenerating muscle—whether from muscular dystrophies, myopathies, or other diseases—loses its mitochondria (the energy supply) and an essential cofactor nicotinamide adenine dinucleotide (NAD+), while gaining an extra load of…
Caenorhabditis elegans (C. elegans) constitutes an important model organism for use in nutrition and aging studies. We report a novel method for studying the dynamics of Escherichia coli (E. coli) bacterial transit…
NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+)…