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  • Early in vivo insights for therapeutic discovery in neurodegeneration

    January 24, 2025
  • Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models.

    Background While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions – e.g. neurodegenerative diseases – often requires long-term studies in animal models. The…

    March 13, 2023
  • TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington’s disease models.

    Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of bona fide…

    March 13, 2023
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