Alzheimer’s disease (AD), the most common form of dementia, is an age-related disease strongly associated with mitochondrial dysfunction and metabolic imbalance, both of which accelerate cellular and neuronal decline. Mitochondrial dysfunction, such…
Background While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions – e.g. neurodegenerative diseases – often requires long-term studies in animal models. The…
Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of bona fide…