"In vivo" tests at the "in vitro" scale

Nagi Bioscience proudly introduces the first Organism-on-Chip technology, which combines the use of a simple yet complete organism for in vivo testing – the tiny worm “Caenorhabditis elegans” – with the first technological platform for its fully automated in vitro handling, culture and analysis. Unprecedented possibilities are now open, for a wide range of applications, including:

Toxicity Testing

Rapid identification of toxic compounds and analysis of toxicological profiles and mechanisms, via real-time monitoring of multiple toxicity endpoints in living C. elegans nematodes.

Drug Discovery

Boosting drug development pipelines, by unleashing the power of C. elegans genetic amenability. Faster compound efficacy tests and mode-of-action studies, for a more efficient lead optimization.

Anthelmintics

“C. elegans-on-chip” as a new tool to test compounds against worm parasitic infections at unprecedented throughput. Drug efficacy and resistance tests, target identification studies.

Bridging the gap...

Bridging the gap...

On one side, unlike cell-based models, our solution allows assessing complete biological responses, only observable at a whole-organism level. On the other side, our technology allows getting these results at automation and throughput levels which are comparable to the cutting-edge of in vitro techniques.

Our Team

Nagi Bioscience is a spin-off project of the Swiss Federal Institute of Technology in Lausanne (EPFL)
Matteo Cornaglia, PhD
Matteo Cornaglia, PhD
Project Co-founder
Laurent Mouchiroud, PhD
Laurent Mouchiroud, PhD
Project Co-founder
Fabien Tâche, PhD
Fabien Tâche, PhD
Head of engineering
Martin Gijs, Prof.
Martin Gijs, Prof.
Scientific Advisor - Microtechnology
Johan Auwerx, Prof. Dr. med
Johan Auwerx, Prof. Dr. med
Scientific Advisor - Biology

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