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  • Streamlining aging studies in C. elegans by end-to-end automated high-throughput analysis

    High-throughput analysis is a challenge in C. elegans research. One example is the conduction of lifespan assays that rely on heavy manual work for a long period of time. In response, we…

    January 30, 2025
  • Unlocking New Frontiers in Aging Research

    Streamlining aging studies: Automated high-content screening for 3Rs in vivo testing at the in vitro scale Streamlining aging studies with automated high-content screening for 3Rs in vivo testing at the in vitro…

    January 24, 2025
  • Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.

    Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in…

    March 13, 2023
  • Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

    In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has…

    March 13, 2023
  • Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

    The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as…

    March 13, 2023
  • Tetracycline-induced mitohormesis mediates disease tolerance against influenza

    Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial stress on…

    March 13, 2023
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