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  • SydLab™ One: An Automated Microfluidic Platform for Scalable, High-Content Toxicological Screening in C. elegans

    Conventional toxicological assays have limitations: cellular models lack organismal complexity, and vertebrate testing is costly, ethically constrained, and low throughput. Caenorhabditis elegans provides a promising alternative, enabling whole-organism testing at an in…

    March 25, 2025
  • Robotic device for fully automated high-content screening on C. elegans as a novel NAMs platform for chemical toxicity assessment

    Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of cultivation and propagation,…

    January 30, 2025
  • A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

    Mitochondrial dysfunction is at the core of many diseases ranging from inherited metabolic diseases to common conditions that are associated with aging. Although associations between aging and mitochondrial function have been identified…

    March 13, 2023
  • An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging.

    Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population’s…

    March 13, 2023
  • Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models.

    Background While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions – e.g. neurodegenerative diseases – often requires long-term studies in animal models. The…

    March 13, 2023
  • An in vivo microfluidic study of bacterial transit in C. elegans nematodes.

    Caenorhabditis elegans (C. elegans) constitutes an important model organism for use in nutrition and aging studies. We report a novel method for studying the dynamics of Escherichia coli (E. coli) bacterial transit…

    March 13, 2023
  • Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution.

    The organism Caenorhabditis elegans is a performant model system for studying human biological processes and diseases, but until now all phenome data are produced as population-averaged read-outs. Monitoring of individual responses to…

    March 13, 2023
  • Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms.

    The nematode Caenorhabditis elegans is an important model organism for biomedical research and genetic studies relevant to human biology and disease. Such studies are often based on high-resolution imaging of dynamic biological…

    March 13, 2023
  • Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans.

    The nematode Caenorhabditis elegans is increasingly used as a model for human biology. However, in vivo culturing platforms for C. elegans allowing high-content phenotyping during their life cycle in an automated fashion…

    March 13, 2023
  • The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms.

    Phenotyping strategies in simple model organisms such as D. melanogaster and C. elegans are often broadly limited to growth, aging, and fitness. Recently, a number of physical setups and video tracking software suites…

    March 13, 2023
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