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  • SydLab™ One: An Automated Microfluidic Platform for Scalable, High-Content Toxicological Screening in C. elegans

    Conventional toxicological assays have limitations: cellular models lack organismal complexity, and vertebrate testing is costly, ethically constrained, and low throughput. Caenorhabditis elegans provides a promising alternative, enabling whole-organism testing at an in…

    March 25, 2025
  • Robotic device for fully automated high-content screening on C. elegans as a novel NAMs platform for chemical toxicity assessment

    Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of cultivation and propagation,…

    January 30, 2025
  • All-in-one microfluidic-based robotic platform for automated toxicity screenings in C. elegans

    We propose an innovative solution for rapid identification of toxic com- pounds and their potential mechanism of toxicity, using a biological model that perfectly bridges the gap between in vitro and in…

    January 30, 2025
  • A robotic device for fully automated high-content screening on C. elegans as novel NAMs for early toxicity assessment

    Background and Objectives Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of…

    January 30, 2025
  • Transforming DART Research

    Automated, fast, and scalable 3Rs in vivo toxicity testing at the in vitro scale.

    January 24, 2025
  • A robotic device for fully automated high-content screening on C. elegans as novel NAMs for chemical toxicity assessment

    Background and Objectives Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of…

    June 26, 2023
  • Worm-on-Chip: fully automated whole-organism platform for screening and identification of toxicity using the nematode Caenorhabditis elegans.

    We describe an innovative platform for fully automated handling and observation of C. elegans, combined with dedicated software for data collection and analysis. Our microfluidic device allows, for the first time, automated high-content phenotyping…

    March 13, 2023
  • Positioning the “Worm-on-Chip” technology as part of the toolbox for NAMs.

    Currently existing toxicology testing still implies an extensive experimentation in mammalian models, which is expensive and associated with important ethical concerns. The alternative methods to animal testing are typically based on cellular…

    March 13, 2023
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