Conventional toxicological assays have limitations: cellular models lack organismal complexity, and vertebrate testing is costly, ethically constrained, and low throughput. Caenorhabditis elegans provides a promising alternative, enabling whole-organism testing at an in…
Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of cultivation and propagation,…
We propose an innovative solution for rapid identification of toxic com- pounds and their potential mechanism of toxicity, using a biological model that perfectly bridges the gap between in vitro and in…
Background and Objectives Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of…
Automated, fast, and scalable 3Rs in vivo toxicity testing at the in vitro scale.
Background and Objectives Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of…
We describe an innovative platform for fully automated handling and observation of C. elegans, combined with dedicated software for data collection and analysis. Our microfluidic device allows, for the first time, automated high-content phenotyping…
Currently existing toxicology testing still implies an extensive experimentation in mammalian models, which is expensive and associated with important ethical concerns. The alternative methods to animal testing are typically based on cellular…