About konstantinos Palikaras’ Lab
The central aim of the group’s research at is to shed light on the molecular mechanisms underlining age-related deterioration of the nervous system.
Led by Professor Konstantinos Palikaras, their research focuses on mitochondrial quality control mechanisms investigating the role of energy metabolism on tissue and organismal homeostasis.
Moreover, their interests involve testing the effects of different natural and chemical compounds on C. elegans physiology and lifespan, developing nematode models of human neurodegenerative diseases and the development of novel genetic tools for biomedical research.
About the project
The research group will use 20 naturally occurring compounds with known mitophagy-inducing properties to investigate their effects on longevity and healthspan in Caenorhabditis elegans.
Additionally, they will explore their therapeutic potential in Alzheimer’s disease (AD) nematode models, specifically those expressing beta-amyloid and Tau proteins.
Using the SydLab™ One platform, the group will evaluate the mitophagy induction and neuroprotective capacities of these compounds, providing insights into their potential to ameliorate neurodegenerative symptoms associated with Alzheimer’s disease. Nagi Bioscience’s SydLab™ One automated platform will allow for precise, high-throughput screening and analysis of the compounds’ effects on the nematode models of interest.
By accelerating research, improving precision, and enhancing reproducibility, SydLab™ One will empower us to explore new frontiers in these critical fields of medical science. We are excited to leverage this fully automated, end-to-end solution in our upcoming projects and accelerate the pace of scientific discovery!
Professor Konstantinos Palikaras,
Group Leader of the Unit of Neurogenetics and Ageing, Laboratory of Physiology, Medical School, NKUA, Palikaras’ Lab
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