Biological Models

Powerful models for powerful datapoints

CAENORHABDITIS ELEGANS

Nature’s gift to science

Meet the powerful model organism

Caenorhabditis elegans has been known for more than 60 years as an important exploratory biological model in fundamental research. It helps in addressing various biological questions in the fields of aging, neurobiology, genomics, and developmental and cellular biology.

Models. in plural.

A world of possibilities opening up

To this date, large amounts of mutant, transgenic and “humanized” worm strains are available. More specifically, C. elegans is distinguished by its ease of genetic manipulations: single genes can be simply inactivated by feeding the worms with bacteria expressing dsRNA against the gene of interest (RNA interference method). Nowadays, any specific strain can be generated easily “on-demand” using modern CRISPR-Cas9 techniques.

stress defense pathways biological models

neurodegenerative disease biological models

pathogen host interactions biological models

strong relevance & proven translatability to human biology

C. elegans is a well-studied model with useful features for rapid investigations.

Keen to know more? Read the Nagi Blog!

C. elegans blog posts

Many pathways important in development, reproduction and modes of toxic action are conserved.

Concordant response areas include growth, development, LD50 ranking and neurotoxicity.

“If we understand the worm, we understand life.”

Sir John Edward Sulston, PhD. 2002 Nobel Prize of Medicine or Physiology

Small. Short life-cycle. not resource-intensive. powerful genetic toolkit.

Data is worth a thousand words

From drug development to toxicology screenings, find out all the areas of application of SydLab™ One.

applications early toxicology assays Enabling small organisms testing

Discover Nagi™ ReproTox and Developmental Toxicity Assays

applications pre-clinical testing Enabling small organisms testing

Gain unleashed datapoints about your candidates

applications aging research Enabling small organisms testing

Use one of the most powerful models for aging studies seamlessly

OUR partners’ word

Failure in later stages of the R&D pipeline is especially costly. We actively pursue technologies to identify adverse toxicology as early as possible, such as Nagi Bioscience’s technologies.

Early Toxicology Safety – Agrochemical Company

Unfavorable toxicological profiles are a major cause of late failure in our discovery pipelines. Failure in later stages of the R&D pipeline is especially costly. We are actively pursuing technologies to identify adverse toxicology as early as possible, including through the use of model systems such as those being investigated by Nagi Bioscience.

Early Toxicology Safety – Agrochemical Company
Methodologies to assess lifespan and healthspan measures in a high-throughput manner are currently inadequate in the C. elegans field. The integration of Nagi’s technology opened many possibilities for us as a company.

CEO – Aging Biotech Company

Before proceeding to clinical trials, the efficacy of our existing drugs or combinations thereof for their positive impact on healthspan will be tested in the nematode C.elegans. However, methodologies to assess lifespan and healthspan measures in a high-throughput manner are currently inadequate in the C. elegans field. The integration of Nagi’s technology into Rejuvenate opened many possibilities for us as a company.

CEO – Aging Biotech Company