From drug discovery to a possible future tool for lung cancer detection. How the Worm-on-chip is revolutionizing the alternative testing methods sector
Last week we reviewed the potential of the nematode C. elegans as a biological model for cancer research, but did you know that new studies indicate that our favorite tiny worms can be used not only in drug development, but also for diagnostics?
The new Lab-on-a-Chip player: The Worm-on-Chip
A Lab-on-a-Chip is a small device integrating one or more lab analyses in a single chip, which allows a substantial reduction in costs and speeds up R&D processes. Other advantages include parallelization, ergonomics, higher diagnostic rapidity and sensitivity. This technology relies either on microfluidics or on molecular biology, and can be used for several applications like DNA analysis, diagnostics, or synthesis of chemicals.
Microfluidics and the origin of Labs-on-a-Chip are intrinsically intertwined. Coming from the necessity of miniaturized components for the Apollo program, microtechnologies and microfabrication were born. And like that, thanks to the development of these technologies, the very first Lab-on-a-Chip was built in 1979 at Stanford University. In the 1990s, researchers started using microfluidics in an attempt to perform biochemical operations in Labs-on-a-Chip.
While the primary focus of those Labs-on-a-Chip was cell biology (since the microchannels and the cells were of the same size), today we assist to a new advanced paradigm: the Worm-on-Chip. Thanks to the small size of the nematode C. elegans, they can easily fit into a microfluidic chip to perform several types of bioassays, from reproductive toxicity to neurodegenerative assays.
The Worm-on-Chip and its applications
Nagi Bioscience proudly introduces the first Organism-on-Chip technology allowing in vivo testing at the in vitro scale, and bridging the gap between cell-based and vertebrate animal models. By using the Nagi’s Chips in our SydLab System, we completely replaced the traditional manual protocols used in C. elegans research. The SydLab System allows, for the first time, the fully automated high content screening of drugs and chemicals on C. elegans.
But what is the future? While the pioneer Nagi’s platform supports multiple bioassays for toxicity and safety assessment of substances, we are convinced that the applications of such technology, along with the robust biological model C. elegans, have a much wider potential in the biotech sector.