Resources

Fully automated laboratory device for aging studies using the nematode Caenorhabditis elegans.

David Liaskos, Elena Katsyuba, Laurent Mouchiroud, Johan Auwerx, Matteo Cornaglia

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.

Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud […] Hilal Lashuel

Journal: EMBO Journal Publication

An in vivo microfluidic study of bacterial transit in C. elegans nematodes.

Author list:

Vittorio Viri, Matteo Cornaglia, Huseyin Baris Atakan, Thomas Lehnert, Martin Gijs

Journal: Lab on a Chip Publication

Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurements.

Author list:

Roger Krenger, Matteo Cornaglia, Thomas Lehnert, Martin Gijs

Journal: Lab on a Chip Publication

Worm-on-a-chip technology: An emerging 3R model in toxicity testing.

Author list:

Carole Mathis, Laurent Mouchiroud, Matteo Cornaglia, Daniel Smart, Mohamed Amin Choukrallah, Karsta Luettich, Julia Hoeng, Manuel Peitsch

Poster

Automated high-content phenotyping of the nematode Caenorhabditis elegans: application to the toxicity assessment of perovskites.

Author list:

Laurent Mouchiroud, Matteo Cornaglia, Alix Pham, Josipa Scurla […] Martin Gijs

Poster

Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans.

Author list:

Huseyin Baris Atakan, Matteo Cornaglia, Laurent Mouchiroud, Johan Auwerx, Martin Gijs

Journal: Lab on a Chip Publication

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution.

Author list:

Maria Cristina Letizia, Matteo Cornaglia, Raphaël Trouillon, Vincenzo Sorrentino, Laurent Mouchiroud, Maroun Bou Sleiman, Johan Auwerx, Martin Gijs

Journal: Microsystems & Nanoengineering Publication

Integrated Microfluidic Device for Drug Studies of Early C. elegans Embryogenesis.

Author list:

Li Dong, Radek Jankele, Matteo Cornaglia, Thomas Lehnert, Pierre Gönczy, Martin Gijs

Journal: Advanced Science Publication

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms.

Author list:

Li Dong, Matteo Cornaglia, Gopalan Krishnamani, Jingwei Zhang, Laurent Mouchiroud […] Martin Gijs

Journal: PLoS One Publication

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Author list:

Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud, John Beck, Hongbo Zhang […] Johan Auwerx

Journal: Nature Publication

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans.

Author list:

Matteo Cornaglia, Thomas Lehnert, Martin Gijs

Journal: Lab on a Chip Publication

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain.

Author list:

Sarah Preston, Pasi Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean McGee, Neil Young […] Robin Gasser

Journal: FASEB Journal Publication

Worm-on-Chip: fully automated whole-organism platform for screening and identification of toxicity using the nematode Caenorhabditis elegans.

Author list:

Laurent Mouchiroud, Matteo Cornaglia, Robert Mader, Martin Gijs, Johan Auwerx

Poster

On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites.

Author list:

Li Dong, Matteo Cornaglia, Thomas Lehnert, Martin Gijs

Journal: Lab on a Chip Publication

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

Author list:

Dongryeol Ryu, Hongbo Zhang, Eduardo Ropelle, Vincenzo Sorrentino, Davi Mázala, Laurent Mouchiroud […] Johan Auwerx

Journal: Science Translational Medicine Publication

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

Author list:

Mandy Koopman, Helen Michels, Beverley Dancy, Rashmi Kamble, Laurent Mouchiroud […] Riekelt H Houtkooper

Journal: Nature Protocols Publication

The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms.

Author list:

Laurent Mouchiroud, Vincenzo Sorrentino, Evan Williams, Matteo Cornaglia, Michael Frochaux […] Johan Auwerx

Journal: Current Protocols in Neuroscience Publication

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Author list:

Dongryeol Ryu, Laurent Mouchiroud, Pénélope Andreux, Elena Katsyuba, Norman Moullan, Amandine Nicolet-Dit-Félix […] Johan Auwerx

Journal: Nature Medicine Publication

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.

Author list:

Carsten Merkwirth, Virginija Jovaisaite, Jenni Durieux, Olli Matilainen, Sabine Jordan, Pedro Quiros, Kristan Steffen, Evan Williams, Laurent Mouchiroud […] Andrew Dillin

Journal: Cell Publication

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models.

Author list:

Matteo Cornaglia, Gopalan Krishnamani, Laurent Mouchiroud, Vincenzo Sorrentino, Thomas Lehnert, Johan Auwerx, Martin Gijs

Journal: Molecular Neurodegeneration Publication

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

Author list:

Norman Moullan, Laurent Mouchiroud, Xu Wang, Dongryeol Ryu, Evan Williams, Adrienne Mottis […] Johan Auwerx

Journal: Cell Reports Publication

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging.

Author list:

Matteo Cornaglia, Laurent Mouchiroud, Alexis Marette, Shreya Narasimhan, Thomas Lehnert, Virginija Jovaisaite, Johan Auwerx, Martin Gijs

Journal: Scientific Reports Publication

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement.

Author list:

Evan Williams, Laurent Mouchiroud, Michael Frochaux, Ashutosh Pandey, Pénélope Andreux, Bart Deplancke, Johan Auwerx

Journal: PLoS Genetics Publication