Biological models

BRIDGING THE GAP BETWEEN CELLS AND VERTEBRates

Powerful models for powerful datapoints

CAENORHABDITIS ELEGANS

Nature’s gift to science

Meet the powerful model organism

Caenorhabditis elegans has been known for more than 60 years as an important exploratory biological model in fundamental research. It helps in addressing various biological questions in the fields of aging, neurobiology, genomics, and developmental and cellular biology.

Models. in plural.

A world of possibilities opening up

To this date, large amounts of mutant, transgenic and “humanized” worm strains are available. More specifically, C. elegans is distinguished by its ease of genetic manipulations: single genes can be simply inactivated by feeding the worms with bacteria expressing dsRNA against the gene of interest (RNA interference method). Nowadays, any specific strain can be generated easily “on-demand” using modern CRISPR-Cas9 techniques.

stress defense pathways biological models
neurodegenerative disease biological models
metabolic disorders biological models
age related diseases biological models
genetic diseases biological models
pathogen host interactions biological models

strong relevance & proven translatability to human biology

rapid model toxicity testing home sydlab one drug discovery toxicology

C. elegans is a well-studied model with useful features for rapid investigations.

Keen to know more? Read the Nagi Blog!

metabolic pathways c elegans biological models

Many pathways important in development, reproduction and modes of toxic action are conserved.

C. elegans biological models for neurotoxicology

Concordant response areas include growth, development, LD50 ranking and neurotoxicity.

“If we understand the worm, we understand life.”

biological models validation for humans

Small. Short life-cycle. not resource-intensive. powerful genetic toolkit.

Data is worth a thousand words

From drug development to toxicology screenings, find out all the areas of application of SydLab™ One.

OUR partners’ word

Unlock the full potential of small organisms with the all-in-one solution Sydlab One

Powerful biological models. powerful technology

First end-to-end automated system for small model organisms testing

tick icon gradient

Easy to integrate in your lab.

tick icon gradient

Tailored to your research.

SydLab One