Rapid in vivo screening of interventions targeting metabolic health and weight management.
Nutraceutical developers need faster in vivo evidence to prioritize ingredients for metabolic health, weight management, and resilience under nutrient excess before committing to slower and more expensive mammalian studies.
Here, we propose a high-glucose C. elegans assay to tackle this industry and health need. Using the Sydlab™ One platform, we developed a streamlined liquid-format assay that captures a coherent glucose-response phenotype across multiple parameters, including survival, reproductive output, censoring-associated pathology, and physiology-linked readouts in a single workflow.
