Background and Objectives Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of…
C. elegans is a powerful model organism for ageing studies. However, the traditional protocols, which continue to be broadly used, rely on manual handling, making them labor-intensive and time-consuming. Automation of these…
We describe an innovative platform for fully automated handling and observation of C. elegans, combined with dedicated software for data collection and analysis. Our microfluidic device allows, for the first time, automated high-content phenotyping…
Here we describe an innovative microfluidic platform using the nematode Caenorhabditis elegans, as an ideal model organism for the study of aging due to its short lifespan and tractable genetics. Our platform allows…
Thanks to its tiny size (1-mm long), the nematode Caenorhabditis elegans can easily fit into a microfluidic chip, offering a new alternative for animal testing and at the in vitro scale. C….
Here we describe an innovative platform which combines the use of the nematode Caenorhabditis elegans, as validated in vivo model for compound screening, with the first laboratory device for its fully automated in vitro culture,…
Currently existing toxicology testing still implies an extensive experimentation in mammalian models, which is expensive and associated with important ethical concerns. The alternative methods to animal testing are typically based on cellular…