Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of cultivation and propagation,…
Currently existing biological testing strategies still involve an extensive animal experimentation in vertebrate models, which is expensive and is associated with a number of important ethical concerns and regulatory constraints. The alternative…
We propose an innovative solution for rapid identification of toxic com- pounds and their potential mechanism of toxicity, using a biological model that perfectly bridges the gap between in vitro and in…
Background and Objectives Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of…
Automated, fast, and scalable 3Rs in vivo toxicity testing at the in vitro scale.
Background and Objectives Nematode Caenorhabditis elegans constitutes a valuable NAMs model for multiple applications, including predictive toxicology. This microscopic worm gained popularity for its ideal short size and life cycle, ease of…
We describe an innovative platform for fully automated handling and observation of C. elegans, combined with dedicated software for data collection and analysis. Our microfluidic device allows, for the first time, automated high-content phenotyping…
Thanks to its tiny size (1-mm long), the nematode Caenorhabditis elegans can easily fit into a microfluidic chip, offering a new alternative for animal testing and at the in vitro scale. C….
Here we describe an innovative platform which combines the use of the nematode Caenorhabditis elegans, as validated in vivo model for compound screening, with the first laboratory device for its fully automated in vitro culture,…
Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of bona fide…