Here we describe an innovative platform which combines the use of the nematode Caenorhabditis elegans, as validated in vivo model for compound screening, with the first laboratory device for its fully automated in vitro culture,…
Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of bona fide…
Currently existing toxicology testing still implies an extensive experimentation in mammalian models, which is expensive and associated with important ethical concerns. The alternative methods to animal testing are typically based on cellular…