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Nagi™ B-Age for Gut Health Innovations

Gut health and microbiome research illustration highlighting biological age measurement in C. elegans as a trait for gut health and probiotic screening and claim substantiation.

Quantify How Gut Health Shapes Biological Age

Nagi™ B-Age for Gut Health integrates intestinal health into biological age assessment, enabling probiotic and functional ingredient innovators to demonstrate whole-organism healthspan impact using the C. elegans model.

Used by leading nutraceutical and functional ingredients innovators

Powered by SydLab™ One automated platform and AI-driven B-Age algorithm

Designed for screening functional ingredient and probiotics where intestinal health plays a central role in healthspan interventions.

The Gut Is a Central Driver of Healthy Aging

The intestine is a central regulator of organismal health. In C. elegans, as in humans, intestinal aging influences: nutrient absorption, metabolic balance, signaling, and systemic stress resistance.

Age‑associated decline in gut integrity accelerates functional deterioration across tissues, contributing to reduced healthspan.

Nagi™ B-Age for Gut Health captures how intestinal aging interacts with other fundamental aging traits, providing a holistic and mechanistically grounded readout of healthspan modulation.

Drug discovery pipeline showing compounds like Urolithin A, Metformin and Nicotinamide Riboside progressing from indication discovery to clinical trials and product to the market, validated by Nagi Bioscience’s C. elegans assays.

Designed for Probiotics and Gut‑Targeting Interventions

Probiotics and live biotherapeutics

Prebiotics and dietary fibers

Postbiotics and microbial metabolites

Fermented ingredients and functional food components

Six Vital Traits defining Nagi™ B-Age for Gut Health

Nagi™ B-Age for Gut Health builds upon the five validated aging traits used in Nagi™ B-Age, while adding a dedicated intestinal dimension:

Nagi Bioscience healthy aging discovery platform illustration showing Swiss-knife style multi-endpoint screening for aging research using C. elegans. Illustrates the six vital traits extracted with the AI-based assay B-Age for Gut Health.
  1. Motility & Neuromuscular Function
    Quantifies age‑dependent decline in locomotion and coordination, reflecting neuromuscular health.
  2. Posture & Morphology
    Assesses age‑related structural changes at the whole‑organism level.
  3. Appearance & Body Integrity
    Measure age related changes in pigmentation of the organism.
  1. Growth & Energy Homeostasis
    Captures age‑associated shifts in energy balance and how the organism chooses among growth and the other vital traits.
  2. Reproduction & Reproductive Span
    Measure the fertility of the organisms, when they start and for how long they generate progenies.
  3. Intestinal Health
    Specifically evaluates age dependent changes in gut functional decline, key targets of probiotic and microbiomefocused interventions.

Together, these 6 traits generate a gut‑aware biological age score that reflects both systemic aging and intestine‑driven healthspan modulation.

Explore Validation Study

Real-world impact: From discovery to insight

C. elegans lifespan and biological age analysis graphs demonstrating probiotic Lactobacillus rhamnosus effects on survival and aging biomarkers.

Insights on biological age reduction

Lactobacillus rhamnosus GG combined with ad libitum feeding resulted in increased early-survival compared to the caloric restriction group, suggesting an even greater beneficial effect on longevity.

See detailed analysis of Vital Traits

Insights into the 6 Vital Traits at day 8

By day 10, the population fed with S. boulardii showed distinct biological age trajectories. Detailed trait analysis revealed dose-dependent improvements in physiological maintenance, resulting in lower biological scores across motility, reproduction, and intestinal health.

See full case study
Biological age vital traits heatmap showing probiotic impact on motility, posture, reproduction, growth and intestinal health in C. elegans aging model.

Recent Projects

Snapshot guide on fast-tracking healthy aging products through multi-endpoint strategies measuring lifespan, healthspan, gut health, and biological age. Including data on Metformin.
Case study from Nagi Bioscience showing probiotic screening for gut health using C. elegans model in collaboration with DTU Biosustain for the Novo Nordisk Foundation.
Case study on testing Lactobacillus rhamnosus probiotics in C. elegans using SydLab One automated longevity screening platform from Nagi Bioscience for healthy aging claims.


A Multi-Endpoint, One-Shot Approach

Nagi™ C-Age and Nagi™ B-Age AI-driven assays bring complementary capabilities that bridge the gap between speed, depth, and predictive value.

Comparison of Nagi Bioscience assays including C-Age and B-Age biological age measurement platform for lifespan and healthspan screening for functional ingredients and biotics for gut health.

Ready to explore Gut‑Driven Healthy Aging?

If your intervention targets the gut, Nagi™ B‑Age for Gut Health provides the missing link between intestinal function and whole‑organism aging outcomes.

Book a Discovery Call