The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain) develops methods and technologies for large-scale production of natural products, sustainable foods, and sustainable biochemicals. Using our proprietary SydLab™ One platform, DTU accelerated the screening of several candidates, unraveling valuable insights into their potential applications for gut health and longevity. Here, we share findings on Saccharomyces boulardii, a probiotic yeast widely used for its beneficial effects on gut health. Emerging evidence suggests that S. boulardii can function as an anti-aging intervention by modulating gut microbiota and intestinal barrier integrity.