Alzheimer’s disease (AD), the most common form of dementia, is an age-related disease strongly associated with mitochondrial dysfunction and metabolic imbalance, both of which accelerate cellular and neuronal decline. Mitochondrial dysfunction, such as mitochondrial hypermetabolism, has been identified as a critical event in the onset and progression of AD. In parallel, caloric restriction (CR) stands out as one of the most robust approaches, consistently demonstrating beneficial effects on healthspan and lifespan across species. Its benefits are closely correlated with preserved mitochondrial integrity, highlighting the central role of mitochondrial function in aging and neurodegenerative processes. As mitochondrial function represents a key feature of aging and Alzheimer’s disease, Prof. Palikara’s research team, specialized in the molecular mechanisms of aging with particular emphasis on mitochondrial homeostasis, used C. elegans Alzheimer’s disease models to investigate how CR influences disease progression and to gain deeper insights into its mechanistic action.
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