Target Age-Related Diseases

Nagi Bioscience banner illustrating research tools for studying and targeting age-related diseases such as neurodegeneration, muscoskeletal conditions, and metabolic disorders.

The Challenge

Age-related diseases such as neurodegeneration, obesity, and metabolic disorders are among the greatest global health burdens.

Researchers and innovators face the daunting task of translating discoveries into therapies that can slow, prevent, or reverse these conditions.

Yet current in vivo preclinical models are often time-consuming  and too costly, leading to high attrition rates in later-stage trials.

Key trends

By 2050, over 1.5 billion people will be aged 65 or older, making age-related diseases a defining medical challenge of our century.

The neurodegeneration therapeutics market is expanding rapidly, driven by the rising prevalence of Alzheimer’s, Parkinson’s, and related disorders, underscoring the urgency for better discovery and validation tools.

There is a clear opening for innovative solutions that enable faster, more predictive, and ethically responsible research into age-related diseases.

With such tools, researchers can accelerate the discovery of interventions that truly improve patient lives.

Automated in vivo results at the in vitro scale:
fast, ethical, and translational solutions

Disease-Relevant in vivo Model

Access a proven in vivo model that speaks the same biological language as human aging. Using C. elegans, we help you rapidly identify compounds that impact healthspan and longevity — ethically, reproducibly, and with direct translational relevance.

Automated, High-Throughput Screening

From experiment design to data analysis, we deliver actionable insights so you can move faster and with confidence.

Are you interested in our flagship solution at your site? Our SydLab™ One platform enables large-scale in vivo testing with reproducible, automated results — saving time and resources while revealing your most promising candidates.

Mechanistic and Biomarker Insights

We combine multi-phenotypic analysis with advanced biological metrics, such as biological age prediction and pathway-specific readouts using fluorescent markers and omic approaches. This equips you with mechanistic understanding, not just outcome data, to be able to de-risk your preclinical programs.

Telomir Pharmaceuticals logo: biotechnology company partnering with Nagi Bioscience in longevity and age-related disease research.
Immunic Therapeutics logo: biotech company advancing immune and neurodegenerative therapeutics with support from Nagi Bioscience.
DTU Biosustain and Novo Nordisk Foundation logo: academic and research collaboration with Nagi Bioscience on healthy aging innovations.
Harvard T.H. Chan School of Public Health logo: leading academic institution leveraging Nagi Bioscience platform SydLab One for aging biology research and metabolism and diet.
Bayer logo: representing research collaborations with Nagi Bioscience in healthy aging innovation and safety in developmental and reproductive toxicity.

Recent Projects

Literature deep dive guide on RNA interference (RNAi) in C. elegans as a tool for studying gene function and therapeutic discovery in age-related diseases.
Case study on caloric restriction (CR) and Alzheimer’s disease progression using Nagi Bioscience’s SydLab™ One and Nagi™ B-Age platforms. Research with C. elegans models from Prof. Palikaras’ lab shows CR improves lifespan, healthspan, motility, and reduces biological age in wild-type and tau40-expressing nematodes, highlighting the role of mitochondrial function in aging and neurodegeneration.
Nature Medicine spotlight article on Urolithin A showing mitophagy induction, lifespan extension in C. elegans, and improved muscle function in rodents. A study supported by Nagi Bioscience C. elegans technology and scientists. Urolithin A is now a commercial product called Mitopure by Timeline (former Amazentis).

With Nagi Bioscience, you gain:

Biological Age insights in as little as 10 days; lifespan and disease-relevant outcomes within weeks.

Screen and validate in vivo compounds earlier, before investing heavily in vertebrate studies.

Enable rapid lead prioritization.

Access robust biomarker and pathway data to strengthen your therapeutic hypotheses.

Reduce costs and your ethical hurdles when applying for vertebrate studies using data rich analysis that justify downstream experiments.

From early-stage discovery to preclinical validation, Nagi Bioscience empowers researchers to fight age-related diseases with confidence, speed, and scientific rigor.

Telomir Pharmaceuticals logo: biotechnology company partnering with Nagi Bioscience in longevity and age-related disease research.

We are very pleased with Nagi Bioscience. Their innovative technology has been instrumental in allowing us to gather critical scientific data quickly, providing invaluable insights that significantly advance our research in longevity.

Immunic Therapeutics logo: biotech company advancing immune and neurodegenerative therapeutics with support from Nagi Bioscience.

“We had a highly positive experience with Nagi’s services. Their innovative assays provided a reliable alternative to mouse studies by leveraging the short lifespan of C. elegans and the high conservation of our target from worms to human.

ElixIRA Pharma AG logo: Longevity Biotech based in Switzerland in partnership with Nagi Bioscience on pre-clinical testing to uncover combining their longevity compounds unlocking synergistic benefits on lifespan and biological age.

Their high-throughput approach provided clear, quantifiable insights into the lifespan and functional effects of our lead combinations— critical data that helped de-risk and prioritize our therapeutic strategy.