C. elegans as an Early In Vivo Model for Gut–Brain Research is a comprehensive review of how this powerful model organism is used to assess and prioritize candidate interventions targeting the gut–brain axis.
This deep-dive showcases how C. elegans enables causal, system-level insights into gut-derived signaling that influences neuronal function, metabolism, and behavior—providing an efficient bridge between in vitro assays and more complex animal models for de-risked decision-making in nutrition, probiotics, metabolic health, and neuroprotection.