In our previous session, we introduced Nagi™ B-Age, a multiparametric phenotypic clock designed to quantify biological aging through integrated vital traits.
In this webinar, we present the evolution of Nagi™ B-Age: the integration of intestinal health into biological age analysis.
Presenting two case studies, one conducted internally on L. rhamnosus GG and one developed in collaboration with the Novo Nordisk Foundation Center for Biosustainability (DTU) on S. boulardii, we demonstrate how intestinal integrity, mobility, reproduction, and additional traits collectively influence biological age trajectories in C. elegans. Intestine-specific morphological parameters combined with the rest of the Nagi™ B-Age vital traits highlight how gut-mediated interventions can be quantitatively linked to measurable shifts in overall biological age.
This framework enables:
- Early detection of functional benefits,
- Reveals dose-dependent effects,
- Supports mechanistic differentiation between strains, cellular fractions, and soluble components.
Speakers
Laurent Mouchiroud, PhD
Chief Scientific Officer of Nagi Bioscience
Laurent carries over 15 years of international experience in aging research and drug discovery across France, the US, and Switzerland. He leads innovation in automated C. elegans screening, has authored 30+ publications in top journals (Nature, Cell), and holds 5 patent applications (2 licensed), driving advances in biomedical and pharmaceutical technologies.
Karl Alex Hedin
Chief Scientific Officer of 1stBiome
Alex is a Swedish scientist with a PhD from Morten Sommer’s lab at the DTU Novo Nordisk Foundation Center for Biosustainability. His research focuses on understanding and engineering microbial systems, translating cutting-edge science into real-world solutions. He is currently co-founder and Chief Scientific Officer of 1stBiome, where they develop next-generation probiotics for a healthier future.
